北京市心肺血管疾病研究所

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研究所概况

现任所领导

马新亮

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博士生导师,北京市心肺血管疾病研究所动脉粥样硬化研究室主任,第八批“千人计划”长期项目入选专家。

研究领域:主要从事缺血性心脏病心肌损伤的发病机制与防治研究。

主持及参与课题:

近年马新亮教授主持了美国NIH基金、AHA和ADA研究基金、及国家杰出青年科学基金等多项课题。

近五年发表SCI文章:

Yu Q, Zhou N, Nan Y, Zhang L, Li Y, Hao X, Xiong L, Lau WB, Ma XL, Wang H, Gao F. Effective glycaemic control critically determines insulin cardioprotection against ischaemia/reperfusion injury in anaesthetized dogs.  Cardiovasc Res. 2014 Jul 15;103(2):238-47. 

Wang Y, Wang X, Lau WB, Yuan Y, Booth D, Li JJ, Scalia R, Preston K, Gao E, Koch W, Ma XL. Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.  Circ Res. 2014 Feb 28;114(5):792-805. 

Zhao J, Wang F, Zhang Y, Jiao L, Lau WB, Wang L, Liu B, Gao E, Koch WJ, Ma XL, Wang Y. Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition.  Circulation. 2013 Sep 10;128(11 Suppl 1):S121-9.  

Sun Y, Yi W, Yuan Y, Lau WB, Yi D, Wang X, Wang Y, Su H, Wang X, Gao E, Koch WJ, Ma XL. C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation.  Circulation. 2013 Sep 10;128(11 Suppl 1):S113-20.  

Wang Y, Zhao J, Zhang Y, Lau WB, Jiao LY, Liu B, Yuan Y, Wang X, Tao L, Gao E, Koch WJ, Ma XL. Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia.  Int J Cardiol. 2013 Oct 3;168(3):2201-6.  

Lau WB, Zhang Y, Zhao J, Liu B, Wang X, Yuan Y, Christopher TA, Lopez B, Gao E, Koch WJ, Ma XL, Wang Y. Lymphotoxin-α is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion.  Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E661-7.  

Su H, Yuan Y, Wang XM, Lau WB, Wang Y, Wang X, Gao E, Koch WJ, Ma XL.  Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNF-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice. Basic Res Cardiol. 2013 Jan;108(1):315. 

Lau WB, Tao L, Wang Y, Li R, Ma XL.  Systemic adiponectin malfunction as a risk factor for cardiovascular disease.  Antioxid Redox Signal. 2011 Oct 1;15(7):1863-73 

Yi W, Sun Y, Gao E, Wei X, Lau WB, Zheng Q, Wang Y, Yuan Y, Wang X, Tao L, Li R, Koch W, Ma XL. Reduced cardioprotective action of adiponectin in high-fat diet-induced type II diabetic mice and its underlying mechanisms. Antioxid Redox Signal. 2011 Oct 1;15(7):1779-88.  

Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res. 2010 Dec 10;107(12):1445-53.   

联系方式:E-mail: Xin.Ma@Jefferson.edu

电话:010-64456095