Jie Du, Professor

Deputy Director of Beijing Institute of Heart, Lung and Blood Vessel Diseases

Research Interests: 

Molecular etiology of CVD, and the mechanisms of cardiovascular pathological remodeling.

Principle Investigator and Projects：

As a principal investigator, Prof. Du directskey projects “Studies on the mechanism of interaction between inflammatory micro-environment and smooth muscle cells in aortic dissection” (2021/01-2024/12) from the National Natural Fund, and the role of interaction network between nucleic acid small molecules and arachidonic acid metabolic small molecules in pathological cardiac remodeling from the National Natural Fund (2018/01-2022/12), and Genetic basis of calcified aortic stenosis in European and Asian populations (2019/01-2021/12).

Selected Publications (from 210 peer reviewed) 

1.Wang Y, Gao P, Li F, Du J. Insights on aortic aneurysm and dissection: Role of the extracellular environment in vascular homeostasis J Mol Cell Cardiol. 2022 Oct; 171:90-101. 

2.Zhang Y, Wang Y, Ke B, Du J. TMAO: how gut microbiota contributes to heart failure. Transl Res. 2021 Feb; 228:109-125

3.Yu H, Rong W, Yang J, Lu J, Ma K, Liu Z, Yuan H, Xu L, Li Y, Jing ZC, Du J. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL): A Novel Biomarker for Prognostic Assessment and Risk Stratification of Acute Pulmonary Embolism. J Clin Med. 2022 Jul 5;11(13):3908. 

4.Li Y, Song L, Rong W, Zhang Y, Yao X, Fang X, Li Y, Du J Exome risk score for predicting susceptibility to and severity of isolated thoracic aortic aneurysm. Hum Mol Genet. 2022 May 5:ddac099.

5.Qi F, Liu Y, Zhang K, Zhang Y, Xu K, Zhou M, Zhao H, Zhu S, Chen J, Li P, Du J. Artificial Intelligence Uncovers Natural MMP Inhibitor Crocin as a Potential Treatment of Thoracic Aortic Aneurysm and Dissection Front Cardiovasc Med. 2022 Apr 1;9:866257. 

6.Ma K, Yang J, Shao Y, Li P, Guo H, Wu J, Zhu Y, Zhang H, Zhang X, Du J, Li Y. Therapeutic and Prognostic Significance of Arachidonic Acid in Heart Failure. Circ Res. 2022 Apr;130(7):1056-1071.

7.Jie Lu, Ping Li, Ke Ma, Yang Li, Hui Yuan, Junming Zhu, Weixun Duan, Jingsong Ou, Yonghong Huang, Long Wu, Xueliang Pan, Hui Zhang, Jie Du & Yulin Li. OPG/ TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection. Nature communications. 2021 Jun 7;12(1):1-0.

8.Yang Li, Shijuan Gao, Yingchun Han, Li Song, Yu Kong, Yao Jiao, Shan Huang, Jie Du & Yulin Li. Variants of focal adhesion scaffold genes cause thoracic aortic aneurysm. Circulation Research. 2021 Jan 8;128(1):8-23.

9.Bokang Qiao, Jing-Jun Nie, Yihui Shao, Yulin Li, Congcong Zhang, Wenjing Hao, Sijin Li, Dafu Chen, Bingran Yu, Hui-Hua Li, Fu-Jian Xu, Jie Du. Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function. Small. 2020,16, 1905925

10.Chen Xu, Yanzhenzi Zhang, Ke Xu, Jing-Jun Nie, Bingran Yu, Sijin Li, Gang Cheng, Yulin Li, Jie Du, Fu-Jian Xu: Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection. Nature Communications 12/2019; 10(1)., 

11.Yulin Li, Boya Chen, Xinying Yang, Congcong Zhang, Yao Jiao, Ping Li, Yan Liu, Zhenya Li, Bokang Qiao, Wayne Bond Lau, Xin-liang Ma, Jie Du. S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocytes Death in Response Ischemic/Reperfusion Injury. Circulation 06/2019; 140 (9), 751-764

12.Ying Zhi, Chen Xu, Dandan Sui, Jie Du, Fu‐Jian Xu, Yulin Li: Effective Delivery of Hypertrophic miRNA Inhibitor by Cholesterol‐Containing Nanocarriers for Preventing Pressure Overload Induced Cardiac Hypertrophy. Advanced Science 04/2019; 6(11):1900023., 

13.Xiaoping Zhang, Chen Xu, Shijuan Gao, Ping Li, Yu Kong, Tiantian Li, Yulin Li, Fu‐Jian Xu, Jie Du. CRISPR/Cas9 Delivery Mediated with Hydroxyl‐Rich Nanosystems for Gene Editing in Aorta. Advanced Science 04/2019; 6(12)., DOI:10.1002/advs.201900386

14.Lei Wang, Yun-Long Zhang, Qiu-Yue Lin, Yu Liu, Xu-Min Guan, Xiao-Lei Ma, Hua-Jun Cao, Ying Liu, Jie Bai, Yun-Long Xia, Jie Du, Hui-Hua Li: CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. European Heart Journal 03/2018; 39(20)., 

15.Yuan Wang, Xin Tan, Hai Gao, Hui Yuan, Rong Hu, Lixin Jia, Junming Zhu, Lizhong Sun, Hongjia Zhang, Lianjun Huang, Dong Zhao, Pei Gao & Jie Du. Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection. Circulation 2018; 137 (3), 259-269

16.Ke Xu, Chen Xu, Yanzhenzi Zhang, Feiran Qi, Bingran Yu, Ping Li, Lixin Jia, Yulin Li, Fu-jian Xu, Jie Du. Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection. Theranostics 01/2018; 8(2):437-449., 

17.Congcong Zhang, Chunxiao Wang, Yulin Li, Takashi Miwa, Chang Liu, Wei Cui, Wen-Chao Song, Jie Du. Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking. Nature Communications 12/2017; 8(1)., 

18.Rui-Quan Li, Yina Wu, Ying Zhi, Xinchao Yang, Yulin Li, Fu-Jian Xu, Jie Du. PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases. Advanced Materials 06/2016; 28(33).