北京市心肺血管疾病研究所

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科研团队

心血管生物学研究室

兰 峰 教授

浏览次数:
字号:
+-14

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研究方向:

基于干细胞的心血管疾病病因学、药物筛选和再生医学治疗研究。

主持及参与课题:

主持青年千人项目基金2014-2017。

国家自然科学基金优秀青年科学基金项目。项目名称:干细胞与心血管疾病转化医学研究。

近年发表SCI文章:(第一作者及责任作者)

1.Wang Y#, Liang P#, Lan F#, Wu H#, Lisowski L, Gu M, Hu S, Kay M, Urnov F, Shinnawi R, Gold J, Gepstein L, Wu J. Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT PhenotypeJ Am Coll Cardiol. 2014;64 (5), 451-459

2.Navarette E#, Liang P#, Lan F#, Sanchez-Freire V, Simmons C, Gong T, Arun Sharma A, Burridge P, Patolla B, Lee AS, Wu H, Beygui R, Wu S, Robbins R, Bers D, Wu JC*. Screening Adverse Drug-Induced Arrhythmia Events Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays. Circulation. 2013;128:S3-13

3.Liang P#, Lan F#, Lee AS#, Gong T, Sanchez-Freire V, Wang Y, Nguyen PK , Bers DM, Robbins RC, Wu JC.Drug Screening Using a Library of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Disease Specific Patterns of Cardiotoxicity Circulation.2013;127:1677-1691

4.Lan F#, Lee AS#, Liang P#, Sanchez-Freire V, Nguyen PK , Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Navarrete EG, Wheeler M, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells. CellStem Cell. 2013;12:101-113.

5.Lan F#, Liu J#, Narsinh KH, Hu S, Han L, Lee AS, Karow M, Nguyen PK, Nag D, Calos MP, Robbins RC, Wu JC. Safe genetic modification of cardiac stem cells using a site-specific integration technique. Circulation. 2012;126:S20-28

6.Liu J#, Narsinh KH#, Lan F#, Wang L, Nguyen PK, Hu S, Lee A, Han L, Gong Y, Huang M, Nag D, Rosenberg J, Chouldechova A, Robbins RC, Wu JC. Early stem cell engraftment predicts late cardiac functional recovery: Preclinical insights from molecular imaging. Circ Cardiovasc Imaging. 2012;5:481-490 

7.Lu WJ#, Lan F#, He Q, Lee A, Tang CZ, Dong L, Lan B, Ma X, Wu JC, Shen L. Inducible expression of stem cell associated intermediate filament nestin reveals an important role in glioblastoma carcinogenesis. Int J Cancer. 2011;128:343-351

联系方式:E-mail:lan1982feng@126.com

电话:010-64456336