<img style="\"HEIGHT:" filter:="" width:="" alt="\"\"" src="\"Sites_OldFiles/xf/admin/uploadfile/201012/2010120811530081.jpg\"" width="99" align="left" border="0" height="131" hspace="20"/>　　杜杰，首都医科大学，北京市心肺血管疾病研究所，教授，博士生导师。1985年北京大学生物系学士，1989年中国农科院取得博士学位，当年赴美国留学。先后作为博士后、讲师、助理教授、副教授在美国Emory University School of Medicine, Baylor College of Medicine 从事心血管，高血压发生及其危害，肿瘤方面的研究。曾主持及参与多项美国NIH R01 心血管研究课题。2008年任教育部长江特聘教授。2008年获得国家自然科学基金杰出青年称号。 2010年教育部心血管重塑相关疾病重点实验室主任。2010年北京市第二批海外高层次人才。2011年教育部长江创新主动脉瘤研究团队主任。

　　目前任北京安贞医院院长助理，北京市心肺血管疾病研究所副所长，教授， 主持包括国家“973”课题，北京市心血管病理生理平台课题，国家自然科学基金重大、重点等基金。累计发表SCI论文已过百篇。

1. Du J*, Jia L, Li Y, Ma X. Add Another Killer for Interfered Vascular Function Natural Killer Cells–Produced Interferon-γ Is a Cue. Arterioscler Thromb Vasc Biol. 2013; 33select 6):1116-7.1.zip
2. Xue H, Xiao Z, Zhang J, Wen J, Wang Y, Chang Z, Zhao J, Gao X, Du J*, Chen YG*. Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling. J Biol Chem.  2013; 288select 21):15006-14.2.zip
3. Zhang Y, Wang Y, Liu Y, Wang N, Qi Y, Du J*. Krüppel-Like Factor 4 Transcriptionally Regulates TGF-β1 and Contributes to Cardiac Myofibroblast Differentiation. PloS One. 2013; 8select 4):e63424.3.zip
4. Zhang JM, Wang Y, Miao YJ, Zhang Y, Wu YN, Jia LX, Qi YF, Du J*. Knockout of CD8 Delays Reendothelialization and Accelerates Neointima Formation in Injured Arteries of Mouse via TNF-α Inhibiting the Endothelial Cells Migration. PloS One. 2013; 8select 5):e62001.4.zip
5. Lin J, LiH, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J*, Han J*. A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Report. 2013; 3select 1):200-10.5.zip
6. Zeng Y, Wang HX, Guo SB, Yang H, Zeng XJ, Fang Q, Tang CS, Du J, Li HH. Transcriptional Effects of E3 Ligase Atrogin-1/MAFbx on Apoptosis, Hypertrophy and Inflammation in Neonatal Rat Cardiomyocyte. PLoS One. 2013; 8select 1):e53831.6.zip
7. Qin YW, Teng X, He JQ, Du J, Tang CS, Qi YF. Increased plasma levels of intermedin and brain natriuretic peptide associated with severity of coronary stenosis in acute coronary syndrome. Peptides. 2013; doi: 10.1016/j.peptides.2013.01.011.7.zip
8. Teng X, Bian Y, Cai Y, Duan X, Yuan F, Du J, Wu W, Wang X, Tang C, Qi Y. Downregulation of Endogenous Intermedin Augmented Myocardial Injury in Rats Ischemic/Reperfusion. Horm Metab Res. 2013; 45select 3):206-12.8.zip
9. Zhang C, Li Y, Wu Y, Wang L, Wang X, Du J*. Interleukin-6/STAT3 pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration. J Biol Chem. 2012; 288select 3):1489-99.9.zip
10. Yang K, Zhang TP, Tian C, Jia LX, Du J, Li HH. Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein Inhibits Angiotensin II-Induced Cardiac Remodeling. Am J Hypertens. 2012; 25select 9):994-1001.10.zip
11. Liu O,  Jia L, Liu X,  Wang Y, Wang X, Qin Y,  Du J, Zhang H. Clopidogrel, a Platelet P2Y12 Receptor Inhibitor, Reduces Vascular Inflammation and Angiotensin II induced-Abdominal Aortic Aneurysm Progression. PLoS One. 2012; 7select 12):e51707.11.zip
12. Qin Y, Cao X, Guo J, Zhang Y, Pan L, Zhang H, Li H, Tang C, Du J, Shi GP. Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovasc Res. 2012; 96select 3):401-10.12.zip
13. Kikani CK, Verona EV,Ryu J,Shen Y, Ye Q, Zheng L, Qian Z, Sakaue H, Nakamura K, Du J, Ji Q, Ogawa w, Sun LZ, Dong LQ, Liu F. Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis. Sci. Signal. 2012; 5select 249):ra80.13.zip
14. Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J. Loss of Glutathione S-transferase A4 Accelerates Obstruction-induced Tubule Damage and Renal Fibrosis. J Pathol. 2012; 228:448-458.14.zip
15. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J*. Serum/glucocorticoid-regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II-induced Inflammation and Cardiac Fibrosis. Arterioscler Thromb Vascular Biol. 2012; 32select 7):1675-86.15.zip
16. Li Y, Zhang C, Wu Y, Han Y, Jia L, Cai L, Li H, Du J*. Deficiency of interleukin-12 promotes CD4 T cell-dependent macrophage differentiation and enhances angiotensin II-induced cardiac fibrosis Arterioscler Thromb Vascular Biol. 2012; 32select 7):1662-74.16.zip
17. Pan L, Li Y, Jia L, Qin Y, Qiu S, Qi G, Cheng J, Qi Y, Li H, Du J*. Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances angiotensin II–induced cardiac inflammation and fibrosis. PLoS One. 2012; 7select 4):e35315.17.zip
18. Ma F, Li Y, Jia L, Han Y, Li H, Qi Y, Du J*. Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF-?/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS One. 2012; 7select 5):e35144. 18.zip
19. Han Y, Li Y, Jia L, Cheng J, Qi Y, Du J*. Reciprocal Interaction between Macrophages and T cells Stimulates Interferon-? and MCP-1 Production in Angiotensin II-induced Cardiac Inflammation and Fibrosis. PLoS One. 2012; 7select 5):e35506.19.zip
20. Zhang L, Dong Y, Dong Y, Cheng J, Du J. The Role of Integrin-β3 in Macrophage Polarization and Regeneration of Injured Muscle. J Biol Chem. 2012; 287select 9):6177-86.20.zip
21. Zhou YB, Zhang J, Cai Y, Teng X, Duan XH, Song JQ, Du J, Tang CS, Qi YF. Insulin resistance induces medial artery calcification in fructose-fed rats. Exp Biol Med select Maywood). 2012; 237select 1):50-7.21.zip
22. Jia L, Li Y, Xiao C, Du J*. Angiotensin II induces inflammation leading to cardiac remodeling. Front Biosci. 2012; 17:221-31.22.zip
23.  Cheng J, Wang Y, Liang A, Jia L, Du J*. Silencing of FSP-1 in Bone Marrow Cells Suppresses Neointima Formation in Vein Graft. Circ Res.  2012; 110select 2):230-40. 23.zip
24.  Zhao D, Qi Y, Zheng Z, Wang Y, Zhang XY, Li HJ, Liu HH, Zhang XT, Du J, Liu J. Dietary factors associated with hypertension. Nat Rev Cardiol. 2011; 8select 8):456-65.24.zip
25.  Teng X, Song J, Zhang G, Cai Y, Yuan F, Du J, Tang C, Qi Y. Inhibition of Endoplasmic Reticulum Stress by Intermededinselect 1-53) Protects Against Myocardioal Injury Through a PI3 kinase-Akt Signaling Pathway. J Mol Med 2011; 89select 12):1195-205.25.zip
26.  Chen G, Lin SC, Chen J, He L, Dong F, Xu J, Han S, Du J, Entman ML, Wang Y. CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. J Am Soc Nephrol. 2011; 22select 10):1876-86.26.zip
27.  Wang Y, Zhao B, Zhang Y, Tang Z, Shen Q, Zhang Y, Zhang W, Du J, Chien S, Wang N. Krüppel-like Factor 4 is Induced by Rapamycin and Mediates the Anti-proliferative Effect of Rapamycin in Balloon-injured Rat Carotid Arteries. Br J Pharmacol. 2012; 165select 7):2378-88.27.zip
28.  Yang SW, Zhou YJ, Nie XM, Liu YY, Du J, Hu DY, Jia DA, Gao F, Hu B, Fang Z, Han HY, Liu XL, Yan ZX, Wang JL, Hua Q, Shi YJ, Li HW; BEAMIS Study Group. Effect of abnormal fasting plasma glucose level on all-cause mortality in older patients with acute myocardial infarction: results from the Beijing Elderly Acute Myocardial Infarction Study select BEAMIS). Mayo Clin Proc. 2011; 86select 2):94-104.28.zip
29. Yang H, Zeng XJ, Wang HX, Zhang LK, Dong XL, Guo S, Du J, Li HH, Tang CS. Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor. Peptides. 2011; 32select 10):2108-15.29.zip
30.  Zhang Y, Kang YM, Tian C, Zeng Y, Jia LX, Ma X, Du J, Li HH. Overexpression of nrdp1 in the heart exacerbates Doxorubicin-induced cardiac dysfunction in mice. PLoS One. 2011; 6select 6):e21104.30.zip
31.  Li JJ, Zhang TP, Meng Y, Du J, Li HH. Stability of F-box Protein Atrogin-1 is Regulated by p38 Mitogen-activated Protein Kinase Pathway in Cardiac H9c2 Cells. Cell Physiol Biochem. 2011; 27select 5):463-70.31.zip
32.  Zheng Y, Wang M, Tian C, Ma X, Chen H, Du J, Li H. Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. J Cell Physiol. 2012; 227select 1):127-35.32.zip
33.  Li W, Rong R, Zhao S, Zhu X, Zhang K, Xiong X, Yu X, Cui Q, Li S, Chen L, Cai J, Du J*. Proteomic analysis of metabolic, cytoskeletal, and stress response proteins in human heart failure. J Cell Mol Med. 2012; 16select 1):59-71.33.zip
34.  Qi G, Jia L, Li Y, Bian Y, Cheng J, Li H, Xiao C, Du J*  Angiotensin II Infusion-Induced Inflammation, Monocytic Fibroblast Precursor Infiltration and Cardiac Fibrosis is Pressure-Dependent. Cardiovasc Toxicol. 2011; 11select 2):157-67.34.zip
35.  Ren J, Yang M, Qi G, Zheng J, Jia L, Cheng J, Tian C, Li H, Lin X, Du J* . Proinflammatory Protein CARD9 is Essential for Infiltration of Monocytic Fibroblast Precursors and Cardiac Fibrosis Caused by Angiotensin II Infusion. Am J Hypertens. 2011; 24select 6):701-7.35.zip
36. Zhang Y, Zeng Y, Wang M, Tian C, Ma X, Chen H, Fang Q, Jia L, Du J*, Li H*. Cardiac-specific overxpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury Basic Res Cardiol. 2011; 106select 3):371-83.36.zip
37.   Li H, Du J, Fan Y, Zhang M, Liu D, Li L, Lockyer P, Kang E, Patterson C, Willis MS. The ubiquitin ligase Muscle Ring Finger-1 select MuRF1) protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun. Am J Pathology. 2011; 178select 3):1043-58.37.zip
38.   Zhang L, Rajan V, Liu E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch W. Pharmacological Inhibition of Myostatin Suppresses Systemic Inflammation and Muscle Atrophy in Mice with Chronic Kidney Disease. FASEB J. 2011; 25select 5):1653-63.38.zip
39.   Cheng J, Wang Y, Ma Y, Yang M, Chan T, Zhang  L, Li H , and Du J*.  The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes neointima formation in vein grafts. Circ Res. 2010; 107select 10):1265-74.39.zip
40. Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J* . Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int. 2010; 78select 7):668-78.40.zip
41. Liu S, Shen H, Xu M, Liu O, Zhao L, Liu S, Guo Z, Du J. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model. Am J Physiol Endocrinol Metab. 2010; 299select 3):E351-63.41.zip
42.   Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML. Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy.  J Mol Cell Cardiol. 2010;49select 3):499-507.42.zip
43.   Wu X, Cheng J, LiP Yang M, Qiu S, Liu P, Du J*.Mechano-Sensitive Transcriptional Factor Egr-1 Regulates Insulin-Like Growth Factor-1 Receptor Expression and Contributes to Neointima Formation in Vein Grafts.  Arterioscler Thromb Vasc Biol. 2010; 30select 3):471-6.43.zip
44.   HuZ, Wang H, Lee IH, Modi S, Wang X, Du J, Mitch WE. PTEN inhibition improves muscle regeneration in mice fed a high fat diet. Diabetes. 2010; 59select 6):1312-20.44.zip
45.   Wang XH, Zhang L, Mitch WE, LeDoux JM, Hu J, Du J*. Caspase-3 cleaves specific 19S proteasome regulatory subunits in skeletal muscle stimulating proteasome activity. J Biol Chem.  2010; 285select 28):21249-57.45.zip
46.   Hu J, Du J, Zhang LP, Pricce RS. Klein J Wang XH. Muscle Specific Expression of XIAP Blocks Proteolysis by Inhibition of Murf-1 in Chronicle Kidney Diseases Mice. J Am Soc Nephrol. 2010; 21select 7):1174-83.46.zip
47.   Zhang LP, Wang XH, Wang H, Du J, Mitch WE. Satellite Cell Dysfunction and Impaired IGF-1 Signaling cause CKD-Induced Muscle Atrophy. J Am Soc Nephrol.  2010; 21select 3):419-27.47.zip
48.   Qin YW, Ye P, He JQ, Sheng L, Wang LY, DU J. Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a \"Western-style diet\" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels. Acta Pharmacol Sin. 2010; 31select 10):1350-8.48.zip
49.   Liu O, Li JR, Gong M, Xu M, Du J*, Zhang HJ. Genetic analysis of six SNPs in candidate genes associated with high cross-race risk of development of thoracic aortic aneurysms and dissections in Chinese Han population. Acta Pharmacol Sin. 2010; 31select 10):1376-80.49.zip
50.   Wang XH, Du J, Klein J, Baiely J and Mitch WE. Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function. Kidney Int.  2009; 76select 7):751-9.50.zip
51.   Zhang LP, Ran LM, Garcia GE, Wang XN, Han SH, Du J*, Mitch WE. Chemokine CXCL16 Regulates Neutrophil and Macrophage Infiltration into Injured Muscle Promoting Muscle Regeneration. Am J Pathol. 2009; 175select 6):2518-27.51.zip
52.   Hu Z, Wang H, Lee IN, Du J*, Mitch WE*. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest. 2009; 119select 10):3059-69.52.zip
53.   Zhang LP, Du J*, Hu Z, Han G, Delafontaine P, Garcia G, Mitch WE. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting.  J Am Soc Nephrol. 2009; 20select 3):604-12.53.zip
54.   Wang X, Hu Z, Du J, Klein J. Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency. Endocrinology.  2008; 149select 11):5384-90.54.zip
55.   Garcia GE, Troung LD, Li P, Zhang P, Du J, Chen JF, Feng L. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. FASEB J. 2008; 22select 2):445-54.55.zip
56.   Zhu Q, Youn H, Tang J, Tawfik O, Dennis K, Terranova PF, Du J, Raynal P, Thrasher JB, Li B. Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene. 2008; 27select 33):4569-79.56.zip
57.   Cheng JZ, Du J*. Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor. Arterioscler Thromb Vasc Biol. 2007; 27select 8):1744-51.57.zip
58.   Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Troung L Boriek AM, Du J*. Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1. J Biol Chem. 2007; 282select 47):34268-75.58.zip
59.   Cheng JZ, Cui RW, Chen C, Du J*. Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology.  2007; 148 select 5): 2085-94.59.zip
60.   Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J and Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes.  2007; 56select 10):2449-56.60.zip
61.   Zhou Q, Du J, Hu Z, Walsh K, Wang XH. Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids. Endocrinology. 2007; 148select 12):5696-705.61.zip
62.   Cheng JZ, Du J*. Mechanical Stretch Simulates Proliferation of Venous Smooth Muscle Cells through Activation of the Insulin-like Growth Factor-1 Receptor. Arterioscler Thromb Vasc Biol. 2007; 27select 8):1744-51.62.zip
63.   Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Troung L Boriek AM, Du J*. Mechanical stretch suppresses Ox-LDL-induced apoptosis in vascular smooth muscle cells by upregulating integrin alphavbeta 3 and stabilization of PINCH-1. J Biol Chem. 2007; 282select 47):34268-75.63.zip
64.   Cheng JZ, Cui RW, Chen C, Du J*. Oxidized Low-density Lipoprotein Stimulates p53-dependent Activation of Pro-apoptotic Bax Leading to Apoptosis of Differentiated Endothelial Progenitor Cells. Endocrinology. 2007; 148 select 5): 2085-94.64.zip
65.   Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes.  2007; 56select 10):2449-56.65.zip
66.   Zhou Q, Du J, Hu Z, Walsh K, Wang XH. Evidence for Adipose-Muscle Crosstalk: Opposing Regulation of Muscle Proteolysis by Adiponectin and Fatty Acids. Endocrinology. 2007; 148select 12):5696-705.66.zip
67.   Wang X, Hu J, Du J, Klein J. X-cheromosome Linked inhibitor of apoptosis protein select XIAP) inhibits muscle proteolysis in insulin deficient mice. Gene Therapy. 2007; 14 select 9): 711-20.67.zip
68.   Ma Y, Zhang L, Peng T, Cheng J, Taneja S, Zhang J, Delafontaine P, Du J*. Angiotensin II Stimulates Transcription of Insulin-like Growth Factor 1 Receptor in Vascular Smooth Muscle Cells: Role of NF-?B. Endocrinology. 2006; 147select 3):1256-63.68.zip
69.   Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE. Development of a Diagnostic Method for Detecting Increased Muscle Protein Degradation in Patients with Catabolic Conditions. J Am Soc Nephrol. 2006; 17select 11):3233-9.69.zip
70.   Wang X, Hu J, Hu Z, Du J, Mitch WE. Insulin Resistance Accelerates Muscle Protein Degradation: Activation of the Ubiquitin-Proteasome Pathway by Defects in Muscle Cell Signaling. Endocrinology. 2006; 147select 9):4160-8.70.zip
71.   Zhang L, Cheng J, Ma Y, Thomas W, Zhang J, Du J*. Dual Pathways for Nuclear Factor ?B Activation by Angiotensin II in Vascular Smooth Muscle: Phosphorylation of p65 by ?B Kinase and Ribosomal Kinase. Circ Res. 2005; 97select 10):975-82.71.zip
72.   Zhang L, Ma Y, Zhang J, Cheng J, Du J*. A New Cellular Signaling for Angiotensin II Activation of NF-?B:  an I?B-independent, RSK-mediated Phosphorylation of p65. Arterioscler Thromb Vasc Biol. 2005; 25select 6):1148-53.72.zip
73.   Zhang L, Cui R, Cheng X, Du J*. Anti-apoptotic Effect of Serum and Glucocorticoid-Inducible Protein Kinase is Mediated by Activating Nuclear Transcription Factor ?B. Cancer Res. 2005; 65select 2): 457-64.73.zip
74.   Song Y, Li Y, Du J, Mitch W., Rosenthal N and Delafontaine P. Muscle-Specific Expression of Insulin-like Growth Factor-1 Blocks Angiotensin II-induced Skeletal Muscle Wasting. J Clin Invest. 2005; 115select 2): 451-8.74.zip
75.   Higashi Y, Peng T, Du J, Sukhanov S, Li Y, Itabe H, Parthasarathy S, Delafontaine P. A Redox-sensitive Pathway Mediates Oxidized LDL-induced Downregulation of Insulin-like Growth Factor-1 Receptor. J Lipid Res. 2005; 46select 6):1266-77.75.zip
76.   Du J, Mitch WE. Identification of Pathways Controlling Muscle Protein Metabolism in Uremia and Other Catabolic Conditions. Curr Opin Nephrol Hypertens. 2005; 14select 4):378-82.76.zip
77.   Du J, Hu Z, Mitch WE. Molecular Mechanisms Activating Muscle Protein Degradation in Chronic Kidney Disease and Other Catabolic Conditions. Eur J of Clin Invest. 2005; 35select 3):157-63.77.zip
78.   Du J, Hu Z, Mitch WE. Cellular Signals Activating Muscle Proteolysis Chronic Kidney Disease: A Two Stage Process. Int Biochem Cell Biol. 2005; 37select 10):2147-55.78.zip
79.   Mitch W, Hu Z, Lee S, Du J. Strategies for Suppressing Muscle Atrophy in Chronic Kidney Disease: Mechanisms Activating Distinct Proteolytic Systems. J Renal Nutrition. 2005; 15select 1): 23-7.79.zip
80.   Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE. Regulation of Muscle Protein Degradation: Coordinated Control of Apoptotic and Ubiquitin-proteasome Systems by Phosphatidylinositol 3 Kinase. J Am Soc Nephrol. 2004; 15 select 6): 1537-45.80.zip
81.   Mitch WE, Du J. Cellular Mechanisms Causing Loss of Muscle Mass in Kidney Disease. Semin Nephrol. 2004; 24select 5): 484-7.81.zip
82.   Du J, Wang X, Miereles C, Bailey J, Zheng B, Price S, Mitch W. Activation of Caspase-3 is an Initial Atep Triggering Accelerated Muscle Proteolysis in Catabolic Conditions. J Clin Invest. 2004; 13select 1):115-23.82.zip
83.   Li Y, HigashiY, Itabe H, Song YH, Du J, Delafontaine P. Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced Cytochrome C Release and Apoptosis via the Phosphatidylinositol 3 Kinase/Akt Signaling Pathway. Arterioscler Thromb Vasc Biol. 2003; 23select 12):2178-84.83.zip
84.   Liao X, Thrasher J, Du J, Li B. GSK-3? Suppression Overcomes TRAIL Resistance in Prostate Cancer. Molecular Cancer Therapy 2003; 3:1215-21.84.zip
85.   Zhang J, Fu M, Myles D, Zhu X, Du J, Cao X, Chen Y. PDGF Induces Osteoprotegerin Expression in Vascular Smooth Muscle Cells by Multiple Signal Pathways. FASEB J. 2002; 521select 1-3):180-4.85.zip
86.   Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H. Shear Stress Stimulates Phosphorylation of eNOS at Ser1179 by Akt-independent Mechanisms - Role of Protein Kinase A. J Biol Chem. 2002; 277select 5): 3388-96.86.zip
87.   Franch H, Sooparb S, Du J .Phosphatidylinositol 3-Kinase Activity is Required for Epidermal Growth Factor to Suppress Proteolysis. J Am Soc Nephrol. 2002; 13select 4):903-9.87.zip
88.   Fu M, Zhu X, Xheng H, Du J, Chen E. Platelet-Derived Growth Factor Promotes the Expression of Peroxisome Proliferator-Activated Receptor ? in Vascular Smooth Muscle Cells by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway. Circ Res. 2001; 89select 11):1058-1064.88.zip
89.   Du J, Brink M, Peng T, Delafontaine P. Thrombin Regulates Insulin-like Growth Factor-1 Receptor Transcription in Vascular Smooth Muscle: Characterization of the Signaling Pathway. Circ Res. 2001; 88select 10):1044-52.89.zip
90.   Franch HA, Sooparb S, Du J, Brown NS. A Mechanism Regulating Proteolysis of Specific Proteins during Renal Tubular Cell Growth. J Biol Chem. 2001; 276select 22):19126-31.90.zip
91.   Price S, Du J, Bailey J, Mitch W.  Molecular Mechanisms Regulating Protein Turnover in Muscle.  Ame J of Kid Diseases. 2001; 37select 1):112-4.91.zip
92.   Du J, Mitch WE, Wang X, Price SR. Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-kappa B. J Biol Chem. 2000; 275select 26):19661-6.92.zip
93.   Du J, Peng T, Scheidegger KJ, Delafontaine, P. Angiotensin II Activation of Insulin-like Growth Factor 1 Receptor Transcription is mediated by a Tyrosine Kinase-Dependent Redox-sensitive Mechanism.  Arterioscler Thromb Vasc Biol. 1999; 19select 9):2119-26.93.zip
94.   Scheidegger K, Du J, Delafontaine P. Distinct and Common Pathways in the Regulation of Insulin-like Growth Factor-1 Receptor Gene Expression by Angiotensin II and Basic Fibroblast Growth Factor. J Biol Chem.1999; 274select 6):3522-30.94.zip
95.   Mitch WE, Du J, Bailey JL, Price SR. Mechanisms Causing Muscle Proteolysis in Uremia: The Influence of Insulin and Cytokines. Miner Electrolyte Metab. 1999; 25select 4-6):216-19.95.zip
96.   Delafontaine P, Brink M, Du J.  Angiotensin II Modulation of Insulin-like Growth Factor 1 Expression in the Cardiovascular System. Trends Cardiova Med. 1996; 6select 6):187-93.96.zip
97.   Du J, Meng XP, Delafontaine P. Transcriptional Regulation of the Insulin-like Growth Factor-1 Receptor Gene: Evidence for Protein Kinase C-dependent and Independent Pathways. Endocrinology 1996; 137select 4):1378-84.97.zip
98.   Du J, Sperling LS, Marrero MB, Phillips L, Delafontaine P. G-protein and Tyrosine Kinase Receptor Cross-talk in Rat Aortic Smooth Muscle Cells: Thrombin- and Angiotensin II-induced Tyrosine Phosphorylation of Insulin Receptor Substrate-1 and Insulin-like Growth Factor 1 Receptor.  Biochem Biophys Res Commun. 1996; 218select 3):934-9.98.zip
99.   Delafontaine P, Meng XP, Ku L, Du J.  Regulation of Vascular Smooth Muscle Cell Insulin-like Growth Factor 1 Receptors by Phosphorothioate Oligonucleotides.  Effects on Cell Growth and Evidence That Sense Targeting at the ATG site Increases Receptor Expression. J Biol Chem. 1995; 270select 24):14383-8.99.zip
100. Du J, Delafontaine P. Inhibition of Vascular Smooth Muscle Cell Growth through Antisense Transcription of a Rat Insulin-like Growth Factor 1 Receptor cDNA. Cir Res. 1995; 76select 6):963-72.100.zip