杜杰教授，1985年毕业于北京大学生物系，1989年赴美国留学。先后作为博士后、助理教授、副教授在美国Emory University School of Medicine, Baylor College of Medicine从事心血管、高血压发生及其危害、肿瘤方面的研究。曾主持及参与多项美国NIH R01心血管研究课题。于2008年回国任教育部长江特聘教授，同年获得国家自然科学基金杰出青年称号。2010年任心血管重塑相关疾病教育部重点实验室主任，2011年任教育部长江创新主动脉瘤研究团队主任。目前任北京市心肺血管疾病研究所副所长。是国家重点研发计划“精准医学研究”项目首席科学家，主持包括科技部“973”课题，北京市心血管病理生理平台课题，国家自然科学基金重大、重点等基金。累计发表SCI论文240余篇。杜杰教授目前担任中华医学会心血管分会基础组副组长、中华生理学会循环生理专业委员会副主任委员、中国动脉粥样硬化委员会常委等。担任Atherosclerosis Thrombus Vascular Biology 副主编，Cardiovascular Research 副主编，Cardiovascular Toxicology 副主编，Current angiogenesis 副主编，《中华分子心脏病学》副主编，中国生理学会循环生理专业学会主任委员，中国病生学会血管医学专业委员会副主任委员，中华医学会心脏病学会基础组副主任等。2014-2018年连续五年被路透出版集团评为中国医学领域高被引科学家之一。2016年获得美国心脏协会授予的“特殊成就奖”。

目前主持课题：

国家自然基金重点项目《炎症微环境在骨骼肌损伤和再生中的作用机制》（2015/01-2019/12）

国家重点研发计划精准医学研究专项《主动脉瘤/夹层分子分型和诊治的精准医学研究》 （2016/07-2019/06）

北京市科技计划“生命科学领域前沿课题”《基于代谢产物的急性心肌梗死分子分型标准研究》（2017/01-2019/12）

国家自然基金重大项目《核酸小分子和花生四烯酸代谢活性小分子调节网络在病理性心肌重构中的作用》（2018/01-2022/12）

国家自然科学基金中加项目《欧洲和亚洲人群主动脉瓣钙化狭窄的遗传基础》（2019/01-2021/12）

近五年发表SCI论文：

1.Zhang X, Xu C, Gao S, Li P, Kong Y, Li T, Li Y*, Xu FJ*, Du J*. CRISPR/Cas9 Delivery Mediated with Hydroxyl-Rich Nanosystems for Gene Editing in Aorta. Adv Sci (Weinh). 2019;6(12):1900386.

2.Yu H, Liu Z, Lu J, Yang X, Yan XX, Mi Y, Hua L, Li Y*, Jing ZC*, Du J*. Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism. Cardiovasc Toxicol. 2019. doi: 10.1007/s12012-019-09525-w.

3.Li Y*, Chen B, Yang X, Zhang C, Jiao Y, Li P, Liu Y, Li Z, Qiao B, Bond Lau W, Ma XL*, Du J*. S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic/Reperfusion Injury. Circulation. 2019;140(9):751-764.

4.Xu C, Zhang Y, Xu K, Nie JJ, Yu B, Li S, Cheng G, Li Y*, Du J*, Xu FJ*.Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection. Nat Commun. 2019;10(1):3184.

5.Zhi Y, Xu C, Sui D, Du J*, Xu FJ*, Li Y*. Effective Delivery of Hypertrophic miRNA Inhibitor by Cholesterol-Containing Nanocarriers for Preventing Pressure Overload Induced Cardiac Hypertrophy. Adv Sci (Weinh). 2019;6(11):1900023.

6.Zhang J, Qu C, Li T, Cui W, Wang X, Du J*. Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration. J Biol Chem. 2019;294(43):15672-15685.

7.You H, Jiang W, Jiao M, Wang X, Jia L, You S, Li Y, Wen H, Jiang H, Yuan H, Huang J, Qiao B, Yang Y, Jin M*, Wang Y*, Du J*. Association of Soluble ST2 Serum Levels With Outcomes in Pediatric Dilated Cardiomyopathy. Can J Cardiol. 2019;35(6):727-735.

8.Qiu S, Liu T, Piao C, Wang Y, Wang K, Zhou Y, Cai L, Zheng S, Lan F*, Du J*. AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation. EJ Cell Mol Med. 2019;23(3):1687-1697.

9.Nie J, Qiao B, Duan S, Xu C, Chen B, Hao W, Yu B, Li Y*, Du J*, Xu F*. Unlockable nanocomplexs with self-acctlerating nucleic acid release for effective staged gene therapy of cardiovascular disease. Adv. Mater. 2018.30(31):570-581.

10.Xu K, Xu C, Zhang Y, Qi F, Yu B, Li P, Jia L, Li Y*, Xu F*, Du J*. Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection. Theranostic. 2018 Jan 1;8(2):437-449.

11.Liu C, Zhang C, Jia L, Chen B, Liu L, Sun J, Zhang W, You B, Li YL, Li ping, Du J*. Interleukin 3 stimulates matrix metalloproteinase 12 production from macrophages promoting thoracic aortic aneurysm/dissection. Clin Sci. 2018. 132(6): 655-668.

12.Wang Y, Tan X, Gao H, Yuan H, Hu R, Jia L, Zhu J, Sun L, Zhang H, Huang L, Zhao D, Gao P*, Du J*. Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection. Circulation. 2018;137:259-269.

13.Pan X#, Shao Y#, Wu F#, Wang Y#, Xiong R, Zheng J, Tian H, Wang B, Wang Y, Zhang Y, Han Z, Qu A, Xu H, Lu A, Yang T, Li X, Xu A, Du J, Lin Z. FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. Cell Metab. 2018 Jun 5;27(6):1323-1337. 

14.Du X, Li Y, Wang Y, You H, Hui P, Zheng Y*, Du J*. Increased branched-chain amino acid levels are associated with long-term adverse cardiovascular events in patients with STEMI and acute heart failure. Life Science. 2018; (209): 167–172.

15.Du X, You H, Li Y, Wang Y, Hui P, Qiao B, Lu J, Zhang W, Zhou S, Zheng Y*, Du J*. Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI. Sci Rep. 2018;8.

16.Ren W#, Liu Y#, Wang X#, Piao C, Ma Y, Qiu S, Jia L, Chen B, Wang Y, Jiang W, Zheng S, Liu C, Dai N, Lan F, Zhang H, Song W-C, Du J*. The Complement C3a-C3aR Axis Promotes Development of Thoracic Aortic Dissection via Regulation of MMP2 Expression. J Immunol. 2018; 200(5):1829-1838. 

17.Piao C, Zhang W-M, Li T-T, Zhang C-C, Qiu S, Liu Y, Liu S, Jin M, Jia L-X, Song W-C, Du J*. Complement 5a stimulates macrophage polarization and contributes to tumor metastases of colon cancer. Exp Cell Res. 2018; 366(2):127-138.

18.Wang Y#, Li X#, Li R, Yang Y, Du J*. Identification of Novel Causal FBN1 Mutations in Pedigrees of Marfan Syndrome. International Journal of Genomics. 2018:1246516.

19.Wang C, Zhang C, Liu L, A X, Chen B, Li Y, Du J. Macrophage-derived mir-155- containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury. Mol Ther. 2017;25 (1):192-204.

20.Li Y, Li Z, Zhang C, Li P, Wu Y, Wang C, Bond Lau W, Ma XL, Du J. Cardiac fibroblast- specific activating transcription factor 3 protects against heart failure by suppressing map2k3-p38 signaling. Circulation. 2017;135(21):2041-2057.

21.Zhang C, Wang C, Li Y, Miwa T, Liu C, Cui W, Song WC, Du J. Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking. Nat Commun. 2017;8(1):2078.

22.Lam S, Wang Y, Li B, Du J, Shui G. Metabolomics through the lens of precision cardiovascular medicine. J Genet Genomics. 2017;44(3):127-138.

23.Jia LX, Zhang WM, Li TT, Liu Y, Piao CM, Ma YC, Lu Y, Wang Y, Liu TT, Qi YF and Du J. ER stress dependent microparticles derived from smooth muscle cells promote endothelial dysfunction during thoracic aortic aneurysm and dissection. Clin Sci (Lond). 2017;131:1287-1299.

24.Jia L, Zhang W, Ma Y, Chen B, Liu Y, Piao C, Wang Y, Yang M, Liu T, Zhang J, Li T, Nie S and Du J. Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction. J Am Heart Assoc. 2017;6.

25.Liu Y, Du J. Precision Medicine in Cardiovascular Diseases. Cardiovascular Innovations and Applications. 2017;2(2):155-161.

26.Zheng S, Shao S, Qiao Z, Chen X, Piao C, Yu Y, Gao F, Zhang J, Du J. Clinical Parameters and Gut Microbiome Changes Before and After Surgery in Thoracic Aortic Dissection in Patients with Gastrointestinal Complications. Sci Rep. 2017;7(1):15228.

27.Cai L, Yu L, Liu S, Li T, Zhang X, Cui W, Du J, Zhang Q. Reconfiguration of NKT Cell Subset Compartment Is Associated with Plaque Development in Patients with Carotid Artery Stenosis. Inflammation. 2017;40(1):92-99.

28.Xiao H, Li H, Wang JJ, Zhang JS, Shen J, An XB, Zhang CC, Wu JM, Song Y, Wang XY, Yu HY, Deng XN, Li ZJ, Xu M, Lu ZZ, Du J, Gao W, Zhang AH, Feng Y, Zhang YY. IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult. Eur Heart J. 2018;39(1):60-69.

29.Yan W, Bi HL, Liu LX, Li NN, Liu Y, Du J, Wang HX, Li HH. Knockout of immunoproteasome subunit β2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice. Biochem Biophys Res Commun. 2017;490(2):84-90.

30.Su Z, Klein JD, Du J, Franch HA, Zhang L, Hassounah F, Hudson MB, Wang XH. Chronic kidney disease induces autophagy leading to dysfunction of mitochondria in skeletal muscle. Am J Physiol Renal Physiol. 2017;312(6):F1128-F1140.

31.Yu H, Zhang L, Liu J, Liu Y, Kowey PR, Zhang Y, Chen Y, Wei Y, Gao L, Li H, Du J, Xia Y. Acquired long QT syndrome in hospitalized patients. Heart Rhythm. 2017;14(7):974-978.

32.Wang F, Li Y, Wu X, Yang M, Cong W, Fan Z, Wang J, Zhang C, Du J, Wang S. Transcriptome analysis of coding and long non-coding RNAs highlights the regulatory network of cascade initiation of permanent molars in miniature pigs. BMC Genomics. 2017;18(1):148.

33.Siu KL, Li Q, Zhang Y, Guo J, Youn JY, Du J, Cai H. NOX isoforms in the development of abdominal aortic aneurysm. Redox Biol. 2017;11:118-125.

34.Kong W, Du J, Zhu Y, Dong E. Basic and Translational Vascular Research in China: Past, Present, and Future. Circ Res. 2017;121(4):335-337.

35.Hu L, Wen Y, Xu J, Wu T, Zhang C, Wang J, Du J, Wang S. Pretreatment with Bisphosphonate Enhances Osteogenesis of Bone Marrow Mesenchymal Stem Cells. Stem Cells Dev. 2017;26(2):123-132.

36.Guo S, Yang L, Liu H, Chen W, Li J, Yu P, Sun ZS, Chen X, Du J, Cai T.Identification of Novel Compound Mutations in PLA2G6-Associated Neurodegeneration Patient with Characteristic MRI Imaging. Mol Neurobiol. 2017;54(6):4636-4643.

37.Qin Y, Wang Y, Liu O, Jia L, Fang W, Du J, Wei Y. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic AneurysmFormation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017;53(3):337-345. 

38.Li RQ, Wu Y, Zhi Y, Yang X, Li Y, Xu FJ, Du J. PGMA‐Based Star‐Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases. Adv Mater. 2016;28(43):9452.

39.Zhang P, Hou S, Chen J, Zhang J, Lin F, Ju R, Cheng X, Ma X, Song Y, Zhang Y, Zhu M, Du J, Lan Y, Yang X. Smad4 deficiency in smooth muscle cells initiates the formation of aortic aneurysm. Circ Res. 2016;118(3):388-99.

40.Guo J, Li Y, Ren YH, Sun Z, Dong J, Yan H, Xu Y, Wang DW, Zheng GY, Du J, Tian XL. Mutant LRP6 Impairs Endothelial Cell Functions Associated with Familial Normolipidemic Coronary Artery Disease. Int J Mol Sci. 2016;17(7). pii: E1173.

41.Lu WW, Jia LX, Ni XQ, Zhao L, Chang JR, Zhang JS, Hou YL, Zhu Y, Guan YF, Yu YR, Du J, Tang CS, Qi YF. Intermedin 1-53 Attenuates Abdominal Aortic Aneurysm by Inhibiting Oxidative Stress. Arterioscler Thromb Vasc Biol. 2016;36(11):2176-2190.

42.Jiang WJ, Ren WH, Liu XJ, Liu Y, Wu FJ, Sun LZ, Lan F, Du J, Zhang HJ. Disruption of mechanical stress in extracellular matrix is related to Stanford type A aortic dissection through down-regulation of Yes-associated protein. Aging. 2016; 8(9):1923-1939. 

43.Zhang WM, Liu Y, Li TT, Piao CM, Liu O, Liu JL, Qi YF, Jia LX, Du J. Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection. J Mol Cell Cardiol. 2016 ;99:76-86.

44.Ren W, Liu Y, Wang X, Jia L, Piao C, Lan F, Du J. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep. 2016;6:28149.

45.Wang L, Zhang TP, Zhang Y, Bi HL, Guan XM, Wang HX, Wang X, Du J, Xia YL, Li HH. Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein. Sci Rep. 2016;6:28399. 

46.Piao C, Zhu Y, Zhang C, Xi X, Liu X, Zheng S, Li X, Guo J, Jia L, Nakanishi T, Cai T, Gu H, Du J. Identification of multiple ACVRL1 mutations in patients with pulmonary arterial hypertension by targeted exome capture. Clin Sci (Lond). 2016;130(17):1559-69.

47.Yu P, Yang W, Han D, Wang X, Guo S, Li J, Li F, Zhang X, Wong SW, Bai B, Liu Y, Du J, Sun ZS, Shi S, Feng H, Cai T. Mutations in WNT10B Are Identified in Individuals with Oligodontia. Am J Hum Genet. 2016; 99(1):195-201.

48.Li TT, Jia LX, Zhang WM, Li XY, Zhang J, Li YL, Li HH, Qi YF, Du J. Endoplasmic reticulum stress in bone marrow-derived cells prevents acute cardiac inflammation and injury in response to angiotensin II. Cell Death Dis. 2016;7(6):e2258.

49.Li J, Chen M, Gao Z, Du J, Yang W, Yin M. Effective approach towards Si-bilayer-IDA modified CoFe2O4 magnetic nanoparticles for high efficient protein separation. Colloids Surf B Biointerfaces. 2016;146:468-74.

50.Chen X, Guo J, Cai T, Zhang F, Pan S, Zhang L, Wang S, Zhou F, Diao Y, Zhao Y, Chen Z, Liu X, Chen Z, Liu Z, Sun Y, Du J. Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes. Sci Rep. 2016;6:26962.

51.Wang T, Wang Z, Yang P, Xia L, Zhou M, Wang S, Du J, Zhang J. PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice. Cell Death Dis. 2016;7:e2176.

52.Sun JY, Li C, Shen ZX, Zhang WC, Ai TJ, Du LJ, Zhang YY, Yao GF, Liu Y, Sun S, Naray-Fejes-Toth A, Fejes-Toth G, Peng Y, Chen M, Liu X, Tao J, Zhou B, Yu Y, Guo F, Du J, Duan SZ. Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κβ Pathways. Arterioscler Thromb Vasc Biol. 2016;36(5):874-85. 

53.Liu J, Yu W, Liu Y, Chen S, Huang Y, Li X, Liu C, Zhang Y, Li Z, Du J, Tang C, Du J, Jin H. Mechanical stretching stimulates collagen synthesis via down-regulating SO2/AAT1 pathway. Sci Rep. 2016;6:21112. 

54.Li TT, Li XY, Jia LX, Zhang J, Zhang WM, Li YL, Qi YF, Du J. Whole Transcriptome Analysis of Hypertension Induced Cardiac Injury Using Deep Sequencing. Cell Physiol Biochem. 2016; 38(2):670-82. 

55.Li H, Jiang W, Ren W, Guo D, Guo J, Wang X, Liu Y, Lan F, Du J, Zhang H. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem Cells Int. 2016;2016:6786184.

56.Che L, Jin Y, Zhang C, Lai T, Zhou H, Xia L, Tian B, Zhao Y, Liu J, Wu Y, Wu Y, Du J, Li W, Ying S, Chen Z, Shen H. Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade. Sci Rep. 2016; 6:18680.

57.Dong Y, Yang M, Zhang J, Peng X, Cheng J, Cui T, Du J *. Depletion of CD8+ T Cells Exacerbates CD4+ T Cell Induced Monocyte-to-Fibroblast Transition in Renal Fibrosis. J Immunol. 2016;196(4):1874-81.

58.Kan X, Wu Y, Ma Y, Zhang C, Li P, Wu L, Zhang S, Li Y, Du J*. Deficiency of il-12p35 improves cardiac repair after myocardial infarction by promoting angiogenesis. Cardiovasc Res. 2016;109(2):249-59.

59.Zhao WJ, Wei SN, Zeng XJ, Xia YL, Du J, Li HH. Gene expression profiling identifies the novel role of immunoproteasome in doxorubicin-induced cardiotoxicity. Toxicology. 2015;333:76-88.

60.Yang M, Liu J, Piao C, Shao J, Du J*. Icam-1 suppresses tumor metastasis by inhibiting macrophage m2 polarization through blockade of efferocytosis. Cell death & disease. 2015;6:e1780.

61.Yang H, Li N, Song LN, Wang L, Tian C, Tang CS, Du J, Li HH, Yu XH, Wang HX. Activation of nod1 by dap contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways. Apoptosis 2015;20:512-522.

62.Wei SN, Zhao WJ, Zeng XJ, Kang YM, Du J, Li HH. Microarray and co-expression network analysis of genes associated with acute doxorubicin cardiomyopathy in mice. Cardiovascular toxicology. 2015;15:377-393.

63.Wang X, Wang HX, Li YL, Zhang CC, Zhou CY, Wang L, Xia YL, Du J*, Li HH*. Microrna let-7i negatively regulates cardiac inflammation and fibrosis. Hypertension. 2015;66:776-785.

64.Wang AW, Song L, Miao J, Wang HX, Tian C, Jiang X, Han QY, Yu L, Liu Y, Du J, Xia YL, Li HH. Baicalein attenuates angiotensin ii-induced cardiac remodeling via inhibition of akt/mtor, erk1/2, nf-kappab, and calcineurin signaling pathways in mice. American journal of hypertension. 2015;28:518-526.

65.Tao W, Wu J, Zhang Q, Lai SS, Jiang S, Jiang C, Xu Y, Xue B, Du J*, Li CJ. Egr1 regulates hepatic clock gene amplitude by activating per1 transcription. Scientific reports. 2015;5:15212.

66.Qiu S, Xiao Z, Piao C, Zhang J, Dong Y, Cui W, Liu X, Zhang Y, Du J*. Ampkalpha2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with ck2beta. The Journal of pathology. 2015;237:330-342.

67.Piao C, Cai L, Qiu S, Jia L, Song W, Du J*. Complement 5a enhances hepatic metastases of colon cancer via monocyte chemoattractant protein-1-mediated inflammatory cell infiltration. The Journal of biological chemistry. 2015;290:10667-10676.

68.Peng X, Zhang J, Xiao Z, Dong Y, Du J*. Cx3cl1-cx3cr1 interaction increases the population of ly6c(-)cx3cr1(hi) macrophages contributing to unilateral ureteral obstruction-induced fibrosis. Journal of immunology. 2015;195:2797-2805.

69.Peng X, Xiao Z, Zhang J, Li Y, Dong Y, Du J*. Il-17a produced by both gammadelta t and th17 cells promotes renal fibrosis via rantes-mediated leukocyte infiltration after renal obstruction. The Journal of pathology. 2015;235:79-89.

70.Meng Y, Chen C, Tian C, Du J, Li HH. Angiotensin ii-induced egr-1 expression is suppressed by peroxisome proliferator-activated receptor-gamma ligand 15d-pgj(2) in macrophages. Cellular physiology and biochemistry. 2015;35:689-698.

71.Liu Y, Wang Y, Shi H, Jia L, Cheng J, Cui W, Li H, Li P, Du J*. Card9 mediates necrotic smooth muscle cell-induced inflammation in macrophages contributing to neointima formation of vein grafts. Cardiovascular research. 2015;108:148-158.

72.Liu X, Jiang T, Piao C, Li X, Guo J, Zheng S, Zhang X, Cai T, Du J*. Screening mutations of mybpc3 in 114 unrelated patients with hypertrophic cardiomyopathy by targeted capture and next-generation sequencing. Scientific reports. 2015;5:11411.

73.Liang M, Wang Y, Liang A, Dong JF, Du J, Cheng J. Impaired integrin beta3 delays endothelial cell regeneration and contributes to arteriovenous graft failure in mice. Arteriosclerosis, thrombosis, and vascular biology. 2015;35:607-615.

74.Jia LX, Zhang WM, Zhang HJ, Li TT, Wang YL, Qin YW, Gu H*, Du J*. Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. The Journal of pathology. 2015;236:373-383.

75.Han QY, Wang HX, Liu XH, Guo CX, Hua Q, Yu XH, Li N, Yang YZ, Du J, Xia YL, Li HH. Circulating e3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction. Clinical science. 2015;128:751-760.

76.Guo L, Tian S, Chen Y, Mao Y, Cui S, Hu A, Zhang J, Xia SL, Su Y, Du J, Block ER, Wang XL, Cui Z. Cat-1 as a novel cam stabilizes endothelial integrity and mediates the protective actions of l-arg via a no-independent mechanism. Journal of molecular and cellular cardiology. 2015;87:180-191.

77.Guo J, Cai L, Jia L, Li X, Xi X, Zheng S, Liu X, Piao C, Liu T, Sun Z, Cai T, Du J*. Wide mutation spectrum and frequent variant ala27thr of fbn1 identified in a large cohort of chinese patients with sporadic taad. Scientific reports. 2015;5:13115.

78.Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS. Regulation of dlk1 by the maternally expressed mir-379/mir-544 cluster may underlie callipyge polar overdominance inheritance. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:13627-13632.

79.Gao H, Guddeti RR, Matsuzawa Y, Liu LP, Su LX, Guo D, Nie SP, Du J*, Zhang M*. Plasma levels of microrna-145 are associated with severity of coronary artery disease. PloS one. 2015;10:e01234774.12.007.