Upper Airway Dysfunction-Related Cardiovascular Diseases Laboratory
Shipeng Shao, Assistant Professor
一、Research Interests
1. Dynamic process of chromatin in mammalian cells;
2. Mechanism of protein liquid-liquid phase separation in chromatin structure and transcription factory;
3. Pathogenic mechanism of protein liquid-liquid phase separation in atherosclerosis.
二、Principal Investigator and Participate Project in 2020
Principal investigator
1. Nuclear actin polymerization regulates transcription through facilitating RNA Pol II phase separa tion from the National Natural Fund (2020/01-2022/12);
2. Nuclear actin polymerization regulates transcription through facilitating RNA Pol II phase separa tion from China Postdoctoral Science Foundation (2019/02-2020/11);
3. Inducible and reversible phase separation of HSF1 mediates transcriptional response during heat shock from China Postdoctoral Science Foundation (2019/09-2020/1).
三、SCI papers published in 2020
1. Chang L, Li M, Shao S, et al. Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells [published online ahead of print, 2020 Nov 5]. Protein Cell. 2020;10.1007/s13238-020-00794-8. (共同第一作者)
四、Scientific Activities
1. Vascular medicine forum : functions and mechanisms of ANGPTL family proteins in regulating lipid metabolism, November 4, 2020
2. Vascular medicine forum: omicsof arachidonic acid metabolic pathway, October 27, 2020
3. Academic report: research and development journey of original cellular energy receptor agonists in China: transformation from basic research to application, October 22, 2020
4. 2020CHC: hot issues in clinical transformation of metabolic related basic research, September 10, 2020
5. Exosomes Forum: research progress of extracellular vesicles in cardiovascular disease, May 13, 2020
6. Seminar on animal models of diseases and biomedicine: Nanjing, December 10, 2020
7. Metabolism - Heart Forum: Beijing, December 18, 2020
Address
E-mail: shaoshipengdq@163.com
Tel: 18510211543
