北京市心肺血管疾病研究所 副所长

一、研究方向

心血管疾病分子病因学研究，心血管病理性重塑发病机制研究。

二、2020 年主持及参与课题

主持国家自然基金重点项目《免疫炎症微环境促进血管平滑肌表型转化导致主动脉夹层的机制研究》(2021/01-2024/12)，国家自然基金重大项目《核酸小分子和花生四烯酸代谢活性小分子调节网络在病理性心肌重构中的作用》(2018/01-2022/12)，教育部创新团队项目《大血管疾病转化医学研究》(2018/01-2020/12)，国家自然科学基金中加项目《欧洲和亚洲人群主动脉瓣钙化狭窄的遗传基础》(2019/01-2021/12)。

三、2020 年发表通讯作者

1. Li Y# , Gao S# , Han Y# , Song L, Kong Y, Jiao Y, Huang S, Du J*, Li YL*. Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm. Circ Res. 2020 Oct 23. (IF= 14.467)

2. Zhang CC, Cheng NN, Qiao BK, Zhang F, Wu J, Liu C, Li YL, Du J*. Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1291-1305.(IF=9.802)

3. Yang XY, Du XY, Ma K, Li GQ, Liu ZH, Rong W, Miao HT, Zhu FL, Cui QH, Wu SW, Li YL*, Du J*.Circulating miRNAs Related to Long-term Adverse Cardiovascular Events in STEMI Patients: A Nested CaseControl Study. Can J Cardiol. 2020 Mar 20;S0828-282X(20)30273-7. (IF=5)

4. Yixin Zhang, Yuan Wang, Bingbing Ke, Jie Du*. TMAO: how gut microbiota contributes to heart failure. Translational research. S1931-5244(20)30203-6 doi: 10.1016/j.trsl.2020.08.007.

5. Cheng N, Liu C, Li Y, Gao S, Han YC, Wang X, Du J*, Zhang C*. MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice. J Biol Chem. 2020 Jul 24;295(30):10212-10223.

6. Zhang C, Cheng N, Qiao B, Zhang F, Wu J, Liu C, Li Y, Du J*. Age-related decline of IFN gamma responses in macrophage impairs satellite cell proliferation and regeneration. J Cachexia Sarcopenia Muscle, 2020.

7. Qiao B, † Nie JJ, † Shao Y, Li Y, Zhang C, Hao W, Li S, Chen D, Yu B, Li HH, Xu FJ, Du J.Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function. Small. 2020 Jan;16(4):e1905925.

8. Exaggerated Autophagy in Stanford Type A Aortic Dissection: A Transcriptome Pilot Analysis of Human Ascending Aortic Tissues. Zeyi Zhou, Yan Liu , Xiyu Zhu , Xinlong Tang , Yali Wang, Junxia Wang, Can Xu , Dongjin Wang , Jie Du* , Qing Zhou*. Genes (Basel). 2020;11(10):1187. (IF=3.759)

9. Effects of Extracellular Matrix Softening on Vascular Smooth Muscle Cell Dysfunction. Shao Y, Li G, Huang S, Li Z, Qiao B, Chen D, Li Y, Liu H*, Du J*, Li P*. Cardiovasc Toxicol. 2020; 20 (6):548-556. (IF=2.284)

10.Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism. Yu H, Liu Z, Lu J, Yang X, Yan XX, Mi Y, Hua L, Li Y, Jing ZC, Du J. Cardiovasc Toxicol. 2020; 20(2):101-110. (IF=2.284)

联系方式

E-mail: jiedu@ccmu.edu.cn

电话: 010-64456030