北京市心肺血管疾病研究所

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科研团队

心血管生物学研究室

李玉琳 副研究员

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+-14

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研究方向:

心血管病理性重塑发病机制研究

主持及参与课题:

1.国家自然基金青年项目《IL-12介导的巨噬细胞分化在心脏纤维化中的机制研究》(2011/01-2013/12)

2.国家自然基金面上项目《α7 尼古丁乙酰胆碱受体抗炎通路在高血压心脏重塑中保护作用及机制》(2015/01-2018/12)

3.北京市科技新星项目《IL-17在高血压致心脏损伤中的临床和基础研究》(2011/01-2013/12)

4.北京市自然基金项目《IL-17介导的骨髓源性纤维细胞活化在高血压心脏纤维化中的机制研究》(2013/01-2015/12)

参与课题:

1.国家自然基金杰出青年项目《心脏纤维化》(2009/01-2012/12)

2.国家自然基金重点项目《炎症微环境在高血压心脏纤维化发病机制中的研究》(2013/01-2016/12)

3.973计划子课题《环境代谢因素通过炎症免疫通路启动高血压发生的机制》(2012.1-2016.12)

近五年发表SCI文章:

1.Li YL, Zhang C, Wu Y, Han Y, Jia L, Cai L, Li H, Du J. Deficiency of interleukin-12 promotes CD4 T cell-dependent macrophage differentiation and enhances angiotensin II-induced cardiac fibrosis. Arteriosclerosis Thrombosis Vasc Biol. 2012; 32(7):1662-1674.

2.Li YL, Wu YN, Zhang CC, Li P, Cui W, Hao JL, Ma XL, Yin ZN,Du J. γδT cell-derivedIL-17A via an IL-β-Dependent Mechanism Mediates Cardiac Injury and Fibrosis inHypertension.Hypertension.2014;64(2):305-14.

3.Li P*, Li YL*, Li ZY, Wu YN, Zhang CC, AX, Wang CX, Shi HT, Hui MZ, XieB, Ahmed M,Du J. Crosstalk between vascular smooth muscle cells and monocytes through IL-1β/IL-18 signaling promotes vein graft thickening. Arteriosclerosis Thrombosis Vasc Biol. 2014;34(9):2001-11.(*共同第一作者)

4.Wu Y,Li YL, Zhang C, A X, Wang Y, Cui W, Li H, Du J. S100a8/a9 Released by CD11b+Gr1+ Neutrophils Activates Cardiac Fibroblasts to Initiate Angiotensin II-Induced Cardiac Inflammation and Injury.Hypertension. 2014;63(6):1241-1250. 

5.Zhang C, Li YL, Wang C, Wu Y, Cui W, Miwa T, Sato S, Li H, Song WC, Du J.Complement 5a Receptor Mediates Angiotensin II-Induced Cardiac Inflammation and Remodeling.Arterioscler Thromb Vasc Biol. 2014;34(6):1240-1248

6.Wang L, Li YL, Zhang CC, Cui W, Wang X, Xia Y, Du J, Li HH. Inhibition of toll-likereceptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation.Cardiovasc Res. 2014:101(3):383-92.

7.Zhao W, Li YL, Jia L, Pan L, Li H, Du J. Atg5 deficiency-mediated mitophagy aggravatescardiac inflammation and injury in response to angiotensin ii. Free radical biology &medicine. 2014;69C:108-115. 

8.Wang YL, Li YL, Wu Y, Jia L, Wang J, Xie B, Hui M, Du J.TNF-α and IL-1β Neutralization Ameliorates Angiotensin II-Induced Cardiac Damage in Male Mice. Endocrinology.2014;155(7):2677-2687. (IF=4.64)  6 

9.Qi GM, Jia LX, Li YL, Li HH, Du J.Adiponectin Suppresses Angiotensin II-Induced Inflammation and Cardiac Fibrosis through Activation of Macrophage Autophagy.Endocrinology. 2014 Jun;155(6):2254-2465.

10.Zhang CC, Li YL, Wu YN, Wang LY, Wang XN, Du J. Interleukin-6/STAT3 pathway isessential for macrophage infiltration and myoblast proliferation during muscle regeneration.The journal of biological chemistry. 2013:288 (3):1489-99.

联系方式:E-mail:lyllyl_1111@163.com

电话:010-64456453